Nano-OligoMed has the ambition to establish and support a network of international exchange, enabling a collaborative scientific team to effectively use a diversity of approaches and strategies to generate and test hybrid nanomaterials for the efficient and safe systemic delivery of oligonucleotide-based therapeutic agents. To this end, we have set-up a joint multidisciplinary scientific collaborative program between 4 European and 3 extra-European institutions, that through exchange, international mobility, and strongly collaborative transfer of knowledge and training activities will bring together leading experts under the field of nanomaterials in biomedicine. The scientific aim of Nano-OligoMed is the creation of degradable hybrid structures that combine different nanostructured materials, as silica, silicon and quatsomes with the delicate programmable oligonucleotides or artificial oligonucleotide-mimic structures. The possibility to develop novel oligonucleotide-based materials will enable a) the degradation of the drug carrier at the presence of a specific input as a function of the intrinsic bio-responsive feature of oligonucleotides, b) the activation of a therapeutic function as a result of the bio-molecular interaction between the oligonucleotide-based material and the molecular target (i.e. miRNAs) and c) the delivery of the chemical payload (DNA and/or artificial mimics, even in combination with cancer drugs) upon cell internalization. The international academic networking possessing a diversity of research skills and the educational activities, will provide to young (PhD students) and senior scientists, specific competences in the field of materials science, nanotechnology, molecular biology and molecular medicine.